Boundary cap cells constrain spinal motor neuron somal migration at motor exit points by a semaphorin-plexin mechanism
نویسندگان
چکیده
منابع مشابه
Integrity of Developing Spinal Motor Columns Is Regulated by Neural Crest Derivatives at Motor Exit Points
Spinal motor neurons must extend their axons into the periphery through motor exit points (MEPs), but their cell bodies remain within spinal motor columns. It is not known how this partitioning is established in development. We show here that motor neuron somata are confined to the CNS by interactions with a neural crest subpopulation, boundary cap (BC) cells that prefigure the sites of spinal ...
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Nerve roots have specialized transition zones that permit axon extension but limit cell movement between the CNS and PNS. Boundary cap cells prevent motor neuron soma from following their axons into the periphery, thereby contributing to a selective barrier. Transition zones also restrict movement of glial cells. Consequently, axons that cross the CNS-PNS interface are insulated by central and ...
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متن کاملMotor neurons and the generation of spinal motor neuron diversity
Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS) controlling a variety of downstream targets. This function infers the existence of MN subtypes matching the identity of the targets they innervate. To illustrate the mechanism involved in the generation of cellular diversity and the acquisition of specific identity, this review will focus on spinal MNs (SpMNs) th...
متن کاملSemaphorins deployed to repel cell migrants at spinal cord borders
In the spinal cord, developing motor neurons extend their axons into the periphery while their cell bodies remain within the motor columns in the spinal cord. Two recent papers show that this partitioning involves forward and reverse semaphorin-plexin signaling between motor neurons and neural crest boundary cap cells.
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ژورنال
عنوان ژورنال: Neural Development
سال: 2007
ISSN: 1749-8104
DOI: 10.1186/1749-8104-2-21